Human Sera
Cayman Chemical DocosapentaenoIc AcId 100mg
A synthetic peptide and peptide dual agonist of GLP-1R and GCGR increases cAMP accumulation in CHO cells overexpressing recombinant human GLP-1R or GCGR (EC50s 6.9 and 10.2 pM respectively) reduces food intake and fat mass as well as improves glucose tolerance in DIO mice at 10 nmol/kg reduces food intake and body weight in wild-type but not Glp1r knockout mice reduces the hepatic lipid percentage in both wild-type and Glp1r knockout mice reduces total hepatic triglycerides diglycerides cholesterol and free fatty acids as well as reduces hepatic inflammation and fibrosis in an ob/ob mouse model of NASH induced by a high-trans fat high-fructose and high-cholesterol diet at 10 nmol/kg
Cayman Chemical Ionone ACD 100mg
An a2-AR agonist selectively binds to a2-ARs over a1-ARs (Kis 0.015 and 5 nM respectively) prevents increases in CTnI as well as reduces myocardial apoptosis pyroptosis and ferroptosis in a mouse model of CLP-induced sepsis at 50 UG/kg induces sedation and decreases mechanical nociception in cats at 40 UG/kg
Cayman Chemical ArachIdonyl m-NItronIlIn 50mg
A G9a and GLP inhibitor (IC50s 9 and 15 nM respectively) selective for G9a and GLP over SET7 SET8 PRMT3 and JMJD2E (IC50s >10000 nM for all) decreases the levels of H3K9me2 in MDA-MB-231 cells (IC50 11 UM) without inducing cytotoxicity (EC50 >40 UM)
Cayman Chemical MIltefosIn 50mg
A minor plant sterol a precursor in the synthesis of various bioactive plant metabolites
Cayman Chemical 1400WhydrochlorIde 100mg
An intermediate in the glucuronic acid pathway prevents increases in ALT and AST activities as well as MDA levels and protects against decreases in cell viability SOD activity and GSH levels induced by ochratoxin A in primary chicken hepatocytes at 1 UG/ml prevents decreases in neuronal excitability and reverses deficits in a visual avoidance assay in a Xenopus model of p-xylene-induced neurotoxicity
Cayman Chemical SIN-1chlorIde 50mg
A TRPC6 inhibitor (IC50 13 nM for the mouse channel) selective for TRPC6 over TRPC3 and TRPC7 (IC50s 1100 and 550 nM respectively for the mouse channels) inhibits TRPC6-mediated reporter gene expression in HEK293T cells expressing mouse TRPC6 at 100 250 and 500 nM decreases myocardial interstitial fibrosis in a mouse model of hypertrophic cardiomyopathy induced by transaortic constriction at 30 mg/kg reduces unilateral ureteral obstruction-induced renal fibrosis in mice increases survival decreases myocardial fibrosis and improves grip strength in a mouse model of DMD at 30 mg/kg
Cayman Chemical DEA Nonate 50mg
An alkaloid with anticancer activity antagonist of Drosophila ecdysteroid receptors in a reporter assay using Drosophila BII cells (EC50 160 UM) reduces the proliferation of and induces apoptosis in CCRF CEM C7H2 leukemia cells at 50 or 100 UM
Cayman Chemical MAHMA Nonate 100mg
A derivative of 6-mercaptopurine has been used as a synthetic intermediate in the synthesis of compounds derived from azathioprine
Cayman Chemical ArachIdoyl glycIn 100mg
A racemic mixture of biotin (R)-sulfoxide and biotin (S)-sulfoxide
Cayman Chemical PIoglItazon 50mg
An inhibitor of ACAT (IC50 44 nM for the rabbit enzyme) reduces plasma and arterial cholesterol levels in rabbits at 1 mg/kg